ThermoStem™

Advancing the Future of Metabolic Health

Obesity, type 2 diabetes, and other metabolic disorders are some of the most pressing global health challenges today. The ThermoStem™ program represents a groundbreaking approach to treating these conditions by harnessing the power of human brown fat-derived stem cells.

Unlike white fat, brown adipose tissue (BAT) plays a key role in regulating metabolic balance. ThermoStem™ is the first platform to develop a human stem cell-based therapy using BAT, opening the door to transformative new treatments.

HOW IT WORKS

Allogeneic Cell-Based Therapy

ThermoStem is an off-the-shelf cell-based therapeutic, meaning the stem cells are not taken from the patient but instead come from a universal donor source. The program incorporates a powerful cell library:

  • Human Brown Adipose Tissue (BAT)
  • White Adipose Tissue (WAT)
  • Brown Adipose-Derived Stem Cells (BADSC)

This innovative platform has successfully demonstrated proof of concept in preclinical models, with strong patent protection supporting ongoing development.

Program Highlights

First human stem cell derived BAT transfer

Creation of first human 3D engineered artificial brown adipose tissue construct (aBAT)

Successful delivery of 3D aBAT construct in mouse model

Transplantation of aBAT lowered blood glucose levels

Transplantation of aBAT decreased weight in obese mice

Published initial proof of concept completed